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KMID : 0378020010440040083
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New Medical Journal
2001 Volume.44 No. 4 p.83 ~ p.90
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An Open Study to Assess the Efficacy and Safety of Seretide®(salmeterol/fluticasone propponate 50/550㎍. strength) in Patients with reversible Airway Obstruction
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최인선/Choi IS
명보현/홍서나/고영일/이신석/주영은/Myung BH/Hong SN/Koh YI/Lee SS/Joo YU
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Abstract
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Background : The most effective long-term medication of chronic asthma is inhaled corticosteroids and it is recommended to use inhaled long acting β2-agonist in addition to inhaled corticosteroid in moderate-to-severe persistent asthmatics. The aim of this study was to investigate the efficacy and safety of Serefide® which is a combination of salmeterol (long-acting β2-agonist) and fluticasone(inhaled corticosteroid) in moderate-to-severe persistaent acthmatics.
Method : Thirty miderate-to-severe persistent asthmatics were enrolled. Following 2-week asthma exacerbation period induced by a withdrawal of inhaled steroid and long acting β2-agonist, the Serefide®(salmeterol/fluticasone 50/500㎍) was added for 4 weeks. Daily recordings of asthma symptom and medication scores and peak expiratory flow(REF), and spirometric measurements of forced expiratory volume in one second(FEV1) every 2 weeks were ferformed. Also, blood samplings were done at baseline and 4th week of the treatment.
Result : Twenty-seven asthmatics completed the study. FEV1 and morning and night PEFs were significantly decreased during the first 2 weeks and 3～4th week of treatment compared with before treatment(p<0.01, respectively). Daytime symptom scores were significantly decreased during 3～4th week of treatment(p<0.05), and the number of days requiring an supplemental salbutamol medication was significantly decreased during the treatment period(p<0.01). No significant adverse effects were observed.
Conclusion : These result suggest that the combination of salmeterol and fluticasone in a single diskus is effective in improving lung function and asthma symptoms with a safety in moderate-to-severe persistent asthmatic subjects.
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